Group Eriksson

RADIEL study group

RADIEL is a lifestyle intervention study aiming at prevention of gestational diabetes (GDM) in high risk women

Gestational diabetes (GDM) is an important risk factor for future type 2 diabetes. As pregnant women are usually amenable to changes that positively contribute to the well-being of their offspring, pregnancy could be a favorable time for lifestyle intervention and prevention of future diabetes. The main aim was to assess the efficacy of a diet and exercise intervention program in women at high diabetes risk.

The RADIEL is a multicenter randomized controlled intervention study targeting women at high risk for GDM. The original study was conducted between 2008 and 2014 in all three maternity hospitals of the Helsinki metropolitan area and in the South-Karelia Central Hospital in Lappeenranta, in Finland. Eligible participants for the study were women aged 18 years, pregnant at, 20 weeks of gestation, with a history of GDM and/or a prepregnancy BMI of 30 kg/m2. Exclusion criteria were type 1 or type 2 diabetes, or GDM diagnosed before 20 weeks of gestation; use of medication that influences glucose metabolism, such as use of oral corticosteroids or metformin; multiple pregnancy; physical disability; current substance abuse; severe psychiatric disorder; and significant difficulty in cooperating.

Study subjects were randomized to an intervention or a control arm. The intervention group received structured diet and exercise counseling while the control group receives standard advice. Multiple anthropometric and laboratory measures were assessed every 3 months until 1 year postpartum. Laboratory measures include a 75 g 2h oral glucose tolerance test (OGTT), upon which the diagnosis of GDM was based.

Follow-up

This study aimed to find the effects of the intervention on the child’s and mother’s long term health, 4-6 years after giving birth and participating in the first part of the study. The 5-year follow-up visits took part in 2013-2017.

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Meinilä J, Valkama A, Koivusalo SB, Stach-Lempinen B, Rönö K, Lindström J, Kautiainen H, Eriksson JG, Erkkola M. Is improvement in the Healthy Food Intake Index (HFII) related to a lower risk for gestational diabetes? Br J Nutr. 2017 May 24:1-7.

Sahrakorpi N, Koivusalo SB, Eriksson JG, Kautiainen H, Stach-Lempinen B, Roine RP. Perceived Financial Satisfaction, Health Related Quality of Life and depressive symptoms in Early Pregnancy. Matern Child Health J. 2017 Feb 3. doi: 10.1007

Meinila J, Valkama A, Koivusalo SB, Rönö K, Kautiainen H, Lindström J, Stach-Lempinen B, Eriksson JG, Erkkola M. Association between diet quality measured by the Healthy Food Intake Index and later risk of gestational diabetes-a secondary analysis of the RADIEL trial. Eur J Clin Nutr. 2017 Apr;71(4):555-557.

Sahrakorpi N, Koivusalo SB, Stach-Lempinen B, Eriksson JG, Kautiainen H, Roine RP. "The Burden of Pregnancy"; heavier for the heaviest? The changes in Health Related Quality of Life (HRQoL) assessed by the 15D instrument during pregnancy and postpartum in different body mass index groups: a longitudinal survey. Acta Obstet Gynecol Scand. 2017 Mar;96(3):352-358.

Meinilä J, Valkama A, Koivusalo SB, Stach-Lempinen B, Lindström J, Kautiainen H, Eriksson JG, Erkkola M. Healthy Food Intake Index (HFII) - Validity and reproducibility in a gestational-diabetes-risk population. BMC Public Health. 2016 Jul 30;16:680.

Grotenfelt NE, Wasenius NS, Rönö K, Laivuori H, Stach-Lempinen B, Orho-Melander M, Schulz CA, Kautiainen H, Koivusalo SB, Eriksson JG. Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes. Diabetologia. 2016 Aug;59(8):1655-8.

Huvinen E, Grotenfelt NE, Eriksson JG, Rönö K, Klemetti MM, Roine R, Pöyhönen-Alho M, Tiitinen A, Andersson S, Laivuori H, Knip M, Valkama A, Meinilä J, Kautiainen H, Stach-Lempinen B, Koivusalo SB. Heterogeneity of maternal characteristics and impact on gestational diabetes (GDM) risk-Implications for universal GDM screening? Ann Med. 2016;48(1-2):52-8.

Valkama A, Koivusalo S, Lindström J, Meinilä J, Kautiainen H, Stach-Lempinen B, Rönö K, Klemetti M, Pöyhönen-Alho M, Tiitinen A, Huvinen E, Laivuori H, Andersson S, Roine R, Eriksson JG. The effect of dietary counselling on food intakes in pregnant women at risk for gestational diabetes: a secondary analysis of a randomised controlled trial RADIEL.Eur J Clin Nutr. 2016 Aug;70(8):912-7.

Metsälä J, Stach-Lempinen B, Gissler M, Eriksson JG, Koivusalo S.Risk of Pregnancy Complications in Relation to Maternal Prepregnancy Body Mass Index: Population-Based Study from Finland 2006-10. Paediatr Perinat Epidemiol. 2016 Jan;30(1):28-37.

Koivusalo SB, Rönö K, Klemetti MM, Roine RP, Lindström J, Erkkola M, Kaaja RJ, Pöyhönen-Alho M, Tiitinen A, Huvinen E, Andersson S, Laivuori H, Valkama A, Meinilä J, Kautiainen H, Eriksson JG, Stach-Lempinen B. Gestational Diabetes Mellitus Can Be Prevented by Lifestyle Intervention: The Finnish Gestational Diabetes Prevention Study (RADIEL): A Randomized Controlled Trial. Diabetes Care. 2016 Jan;39(1):24-30.

Engberg E, Stach-Lempinen B, Sahrakorpi N, Rönö K, Roine RP, Kautiainen H, Eriksson JG, Koivusalo SB. A cross-sectional study of antenatal depressive symptoms in women at high risk for gestational diabetes mellitusJ Psychosom Res. 2015 Dec;79(6):646-50.

Meinilä J, Koivusalo SB, Valkama A, Rönö K, Erkkola M, Kautiainen H, Stach-Lempinen B, Eriksson JG. Nutrient intake of pregnant women at high risk of gestational diabetes.Food Nutr Res. 2015 May 19;59:26676.

Miettinen HE, Rönö K, Koivusalo S, Stach-Lempinen B, Pöyhönen-Alho M, Eriksson JG, Hiltunen TP, Gylling H. Elevated serum squalene and cholesterol synthesis markers in pregnant obese women with gestational diabetes mellitus. J Lipid Res. 2014 Dec;55(12):2644-54.

Rönö K, Stach-Lempinen B, Klemetti MM, Kaaja RJ, Pöyhönen-Alho M, Eriksson JG, Koivusalo SB; RADIEL group. Prevention of gestational diabetes through lifestyle intervention: study design and methods of a Finnish randomized controlled multicenter trial (RADIEL). BMC Pregnancy Childbirth. 2014 Feb 14;14:70.

Samfundet Folkhälsan

Academy of Finland

European Commission

Finska Läkaresällskapet (“Medical Society of Finland”)

Medicinska Understödsföreningen Liv och Hälsa (“Life and Health Medical Fund”)

 

Professor Katri Räikkönen, UH

Professor Tessa Roseboom, AMC, the Netherlands

Personnel

 

Senior Scientists

Mikaela von Bonsdorff, PhD

Hannu Kautiainen, PhD

Merja Laine, MD, DMSc

Tuija Mikkola PhD, administrative leader

 

Post-Doctoral Scientists

Jelena Meinilä, PhD

Mia Perälä, PhD

Minna Salonen, Data Manager

Niko Wasenius, PhD

 

Graduate Students

Hanna Jantunen

Jannica Selenius

Anna Westberg

Max Åström

 

Staff

Hanna Oksa, Research Nurse

Maria Finne, Project Coordiantor

Sigrid Rosten, Data Manager

Contact

    • Johan Eriksson

      MD, DMSc, Professor, Program Director

    • Tel:
      +358 91 912 7557

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