Group Eriksson

Developmental Origins of Health and Disease

The concept of Developmental Origins of Health and Disease (DOHaD) has provided new insights into the early origins of health and disease from a life course perspective. Non-optimal early life conditions are associated with an increased risk for several non-communicable diseases including coronary heart disease, type 2 diabetes and stroke.

We initiated the Helsinki Birth Cohort Study (HBCS) in 1994. One primary aim of HBCS is to assess how growth and environmental factors acting during early life are related to health in adult life. Besides taking into account early life factors, socioeconomic and adult lifestyle factors are also considered, as well as genetic factors. In other words health and disease are focused upon from a life course perspective. Our particular focus has been to study the early life origins of cardiovascular disease and its risk factors, cognitive function, psychological and behavioral outcomes as well as aging-related processes.

The EU Horizon 2020 project DynaHealth started focusing upon “Dynamics and Determinants of Life Course Health and Wellbeing”.
Within the HBCS we focus upon healthy and active aging from a life course perspective. Follow-up of mothers and children in the gestational diabetes (GDM) prevention study continues.

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Senior Scientists

Hannu Kautiainen, PhD

Mikaela von Bonsdorff, PhD

Post-Doctoral Scientists

Minna Salonen, PhD

Monica von Bonsdorff, PhD

Niko Wasenius, PhD

Mia Perälä, PhD

Graduate Students

Markus Haapanen

Anna Westberg

Staff

Maria Finne, Research Assistant

Terttu Nopanen, Research Nurse

Hanna Oksa, Research Nurse

Paula Nyholm, Research Nurse

Sigrid Rosten, MSc

Eriksson JG, Forsen T, Tuomilehto J, Winter PD, Osmond C, Barker DJ. Catch-up growth in childhood and death form coronary heart disease: longitudinal study. BMJ 1999;318:427-31

Eriksson JG, Forsén T, Tuomilehto J, Osmond C, Barker DJP. Early growth and coronary heart disease in later life: longitudinal study. BMJ 2001;322:949-53

Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M for the Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001;344:1343-9

Eriksson JG, Lindi V, Uusitupa M, Forsen TJ, Laakso M, Osmond C, Barker DJ. The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes 2002;51:2321-4

Barker DJP, Osmond C, Forsen TJ, Kajantie E, Eriksson JG. Trajectories of growth among children who later have coronary event. New Engl J Med 2005; 353: 1802-9

von Bonsdorff MB, Rantanen T, Sipilä S, Salonen MK, Kajantie E, Osmond C, Barker DJP, Eriksson JG. Birth Size and Childhood Growth as Determinants of Physical Functioning in Older Age: the Helsinki Birth Cohort Study. American Journal of Epidemiology 2011;174:1336-44

Eriksson JG, Sandboge S, Salonen MK, Kajantie E, Osmond C. Long-term consequences of maternal overweight in pregnancy on offspring later health: Findings from the Helsinki Birth Cohort Study. Ann Med. 2014 Sep;46(6):434-8

Khulan B, Manning JR, Dunbar DR, Seckl JR, Raikkonen K, Eriksson JG, Drake AJ. Epigenomic profiling of men exposed to early-life stress reveals DNA methylation differences in association with current mental state. Transl Psychiatry. 2014 Sep 23;4:e448

Mikkola TM, von Bonsdorff MB, Osmond C, Salonen MK, Kajantie E, Cooper C, Välimäki MJ, Eriksson JG. Childhood growth predicts higher bone mass and greater bone area in early old age: findings among a subgroup of women from the Helsinki Birth Cohort Study. Osteoporos Int. 2017 Apr 25. doi: 10.1007/s00198-017-4048-6. [Epub ahead of print]

Korhonen PE, Kautiainen H, Eriksson JG. The shorter the person, the higher the blood pressure: a birth cohort study. J Hypertens. 2017 Jun;35(6):1170-1177.

Hirvonen K, Laivuori H, Lahti J, Strandberg T, Eriksson JG, Hackman P. SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men. BMC Med Genet. 2017 Apr 11;18(1):41

Perälä MM, von Bonsdorff MB, Männistö S, Salonen MK, Simonen M, Kanerva N, Rantanen T, Pohjolainen P, Eriksson JG. The healthy Nordic diet predicts muscle strength 10 years later in old women, but not old men. Age Ageing. 2017 Mar 10:1-6

Eriksson JG, Guzzardi MA, Iozzo P, Kajantie E, Kautiainen H, Salonen MK. Higher serum phenylalanine concentration is associated with more rapid telomere shortening in men. Am J Clin Nutr. 2017 Jan;105(1):144-150

Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VW, Eriksson JG, Broekman BF. Influence of maternal obesity on the long-term health of offspring.

Lancet Diabetes Endocrinol. 2017 Jan;5(1):53-64

Rantalainen V, Lahti J, Henriksson M, Kajantie E, Tienari P, Eriksson JG, Raikkonen K. APOE and aging-related cognitive change in a longitudinal cohort of men. Neurobiol Aging. 2016 Aug;44:151-8

Honka MJ, Bucci M, Andersson J, Huovinen V, Guzzardi MA, Sandboge S, Savisto N, Salonen MK, Badeau RM, Parkkola R, Kullberg J, Iozzo P, Eriksson JG, Nuutila P.

Resistance training enhances insulin suppression of endogenous glucose production in elderly women. J Appl Physiol (1985). 2016 Mar 15;120(6):633-9

Surakka I, Horikoshi M, Mägi R, Sarin AP, Mahajan A, Lagou V, Marullo L, Ferreira T, Miraglio B, Timonen S, Kettunen J, Pirinen M, Karjalainen J, Thorleifsson G, Hägg S, Hottenga JJ, Isaacs A, Ladenvall C, Beekman M, Esko T, Ried JS, Nelson CP, Willenborg C, Gustafsson S, Westra HJ, Blades M, de Craen AJ, de Geus EJ, Deelen J, Grallert H, Hamsten A, Havulinna AS, Hengstenberg C, Houwing-Duistermaat JJ, Hyppönen E, Karssen LC, Lehtimäki T, Lyssenko V, Magnusson PK, Mihailov E, Müller-Nurasyid M, Mpindi JP, Pedersen NL, Penninx BW, Perola M, Pers TH, Peters A, Rung J, Smit JH, Steinthorsdottir V, Tobin MD, Tsernikova N, van Leeuwen EM, Viikari JS, Willems SM, Willemsen G, Schunkert H, Erdmann J, Samani NJ, Kaprio J, Lind L, Gieger C, Metspalu A, Slagboom PE, Groop L, van Duijn CM, Eriksson JG, Jula A, Salomaa V, Boomsma DI, Power C, Raitakari OT, Ingelsson E, Järvelin MR, Thorsteinsdottir U, Franke L, Ikonen E, Kallioniemi O, Pietiäinen V, Lindgren CM, Stefansson K, Palotie A, McCarthy MI, Morris AP, Prokopenko I, Ripatti S; ENGAGE Consortium. The impact of low-frequency and rare variants on lipid levels. Nat Genet. 2015 Jun;47(6):589-97

Samfundet Folkhälsan

Academy of Finland

European Commission

Finska Läkaresällskapet (“Medical Society of Finland”)

Medicinska Understödsföreningen Liv och Hälsa (“Life and Health Medical Fund”)

Gyllenberg Foundation

The Swedish Cultural Foundation in Finland

Sture Andersson, Professor

Katri Räikkönen, Professor

Clive Osmond, Professor

Marjo-Riitta Järvelin, Professor

Cyrus Cooper, Professor

Kent Thornburg, Professor

Tessa Roseboom, Professor

Päivi Korhonen, Professor

Peter Nilsson, Professor

Patricia Iozzo, Associate Professor

Eero Kajantie, Associate Professor