Group Kere

Early Embryo Development and Complex Human Disorders

We focus on gene effects and networks in complex human phenotypes. We study early embryonic development and complex disorders, many with an inflammatory component, such as pre-eclampsia, psoriasis, and rare immune system-related diseases, as well as developmental dyslexia. In addition, our group has an interest in comparative studies between human and other species, such as the dog. There is a strong strategic synergy between the projects, even though they represent different physiological systems.

Our research group was established in 1994. We use modern genomics tools, including high-throughput DNA and RNA sequencing. We work in tight collaboration with clinical specialists as well as leading experts on special methods, such as proteomics, single-cell transcriptomics, and brain imaging, and are involved in a number of international consortia. 

Our recent major breakthrough provided a detailed transcriptome of early embryos, and now our focus is to characterise the regulatory network of early embryonic development. Our recent work has highlighted the functions of DUX4, a gene that launches the activation of the embryo’s own genome. We have recently found that a central mechanism in pre-eclampsia involves an autoimmune-like process when the protection of placental cells by the expression of a gene called HLA-G is low and the mother’s immune system can more strongly attack the placenta. In psoriasis, we showed that innate immunity related signaling pathways are active also in non-immune cells of psoriatic skin. We have identified several susceptibility genes, e.g., for dyslexia, providing opportunities to study the pathogenetic mechanisms. We are currently studying the relationship between dyslexia susceptibility genes and brain activity. Our studies on immune deficiency disorders are focused on identifying genes behind the new and rare types of diseases. We have already identified several new genes with work ongoing on yet new genes.

 

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Senior Scientists

Outi Elomaa, PhD, Docent, Administrative Group Leader
Sini Ezer, PhD
Shintaro Katayama, PhD
Satu Wedenoja, MD, PhD, Associated researcher

Undergraduate Students

Lisa Gawriyski, MSc
Inka Häkkinen, BM
Elina Tuovinen, BM

Staff

Eira Leinonen, Research Nurse
Auli Saarinen, Laboratory Assistant

Wedenoja S*, Yoshihara M, Teder H, Sariola H, Gissler M, Katayama S, Wedenoja J, Häkkinen IM, Ezer S, Linder N, Lundin J, Skoog T, Sahlin E, Iwarsson E, Pettersson K, Kajantie E, Mokkonen M, Heinonen S, Laivuori H, Krjutškov K, Kere J*. Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia. EBiomedicine 2020

https://doi.org/10.1016/j.ebiom.2020.102872

 

Wagner M, Yoshihara M, Douagi I, Damdimopoulos A, Panula S, Petropoulos S, Lu H, Pettersson K, Palm K, Katayama S, Hovatta O, Kere J, Lanner F, Damdimopoulou P. Single cell map of the human ovarian cortex. Nature Commun 11:1147, 2020

https://pubmed.ncbi.nlm.nih.gov/32123174/ 

 

Hirabayashi S, Bhagat S, Matsuki Y, Takegami Y, Uehata T, Kanemaru A, Itoh M, Shirakawa K, Takaori-Kondo A, Takeuchi O, Carninci P, Katayama S, Hayashizaki Y, Kere J, Kawaji H, Murakawa Y. NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements. Nature Genet 51:1369-1379, 2019 

https://pubmed.ncbi.nlm.nih.gov/31477927/

 

Katayama S, Ranga V, Jouhilahti E-M, Airenne TT, Johnson MS, Mukherjee K, Bürglin TR*, Kere J*. Phylogenetic and mutational analyses of human LEUTX, a homeobox gene implicated in embryogenesis. Sci Rep 8:17421, 2018

https://pubmed.ncbi.nlm.nih.gov/30479355/

 

Weltner J, Balboa D, Katayama S, Bespalov M, Krjutškov K, Jouhilahti E-M, Trokovic R, Kere J*, Otonkoski T*. Human pluripotent reprogramming with CRISPR dCas9 activators. Nature Commun 9:2643, 2018

https://pubmed.ncbi.nlm.nih.gov/29980666/

 

Töhönen V, Katayama S, Vesterlund L, Jouhilahti E-M, Sheikhi M, Madissoon E, Filippini-Cattaneo G, Jaconi M, Johnsson A, Bürglin TR, Linnarsson S, Hovatta O, Kere J. Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development. Nature Commun 6:8207, 2015

https://pubmed.ncbi.nlm.nih.gov/26360614/

Folkhälsan Research Foundation

Jane and Aatos Erkko Foundation

Medicinska Understödsföreningen Liv Och Hälsa (Life and Health Medical Fund)

Päivikki and Sakari Sohlberg Foundation 

Sigrid Juselius Stiftelse

Dyslexia consortium “DYSGEBRA”: Heikki Lyytinen, PhD, Professor, and Riitta Salmelin, DSc, Professor

Hannele Laivuori, MD, PhD

Hannes Lohi, PhD, Professor

Timo Otonkoski, MD, PhD, Professor

Mikko Seppänen, MD, PhD

Juha Tapanainen, MD, PhD, Professor

Contact

    • Juha Kere

      MD, PhD, Professor, Group Leader

    • Tel:
      +46 73 421 3550

    • Contact
    • Outi Elomaa

      PhD, Docent, Administrative Group Leader

    • Tel:
      +358 50 448 5664

    • Contact